By botao Atrium R&D • Blog • Science • • • • • • • • 0 Comments

At the Edge of Innovation

At the Edge of Innovation:
Advanced Delivery Systems for Ambitious OEM Projects in the USA

R&D + Manufacturing in the USA for oral care, sublingual films, multi-chamber systems, suppositories, and dietary supplements

Who We Are

We are a US-based OEM/ODM that specializes in difficult, multi-component formulations — from professional in-office teeth-whitening systems engineered for summer heat-stability, to sublingual / orodispersible films (ODF) with high active loads, multi-chamber peroxide / activator dispensers, science–driven suppository delivery systems, and dietary supplement innovations. We combine rapid prototyping, analytical rigor, and design-for-scale manufacturing to move ideas from lab to launch on US timelines.

Why Customers Choose Us for the
“Too Hard” Projects

  • Polymer-science DNA: We formulate with cellulose ethers, crosslinkable acrylates, block copolymers, PEG/lipid matrices, and smart rheology modifiers to tune adhesion, occlusion, and release.
  • Event-temperature stability engineering: We design for 50 °C summer shipping, validated by accelerated stability.
  • Multi-component architecture: Experience with binary systems (e.g., peroxide + activator) in dual-barrels, and two-stage strips.
  • Regulatory-ready files: Cosmetic dossiers, ISO 22716 cosmetics GMP alignment, device-adjacent documentation where appropriate; US-based.
  • Launch credibility: We have taken prestige beauty, dental, and Amazon-first brands from formulation to commercial scale – successfully launched on Sephora, Ulta, CVS, Amazon, and featured on Good Morning America multiple times; references and technical dossiers available under NDA.

Our Specialties

Oral-Care Systems: Whitening, Remineralization

  • Professional & at-home whitening:
    • Summer heat-stable peroxide systems (hydrogen peroxide) using oxygen-occlusion yet peroxide-compatible polymers, radical scavenger tuning, and water-activity control to maintain potency after 2 years.
    • Sensitivity-relieving activator (e.g., buffered catalysts) designed to co-mix in dual-chamber delivery systems with matched viscosities (±10%) for dose accuracy.
  • Remineralization & desensitizing: Nano-hydroxyapatite (n-HAp), Arginine-Calcium, and Potassium Nitrate systems, and bioadhesive film formers to extend dwell time on enamel.

Orally Disintegrating / Sublingual Films (ODF)

  • High-load films (up to 25–35% actives depending on API/supplement) with taste-masking, high absorption / bioavailability and moisture control.
  • Micro-encapsulation to protect sensitive ingredients.
  • Fast disintegration targets (≤30–60 s).

Multi-Chamber Dispensers & Two-Step Strips

  • Oxygen-barrier packaging to protect peroxide or volatile actives.
  • Two-step strips that combine activator + substrate on use; validated mixing kinetics and on-tooth adhesion.

Suppository Delivery Systems

  • Lipid-base matrices, melting point tuning (33–37 °C), sedimentation control for suspended actives.
  • Release profiling via in-vitro dissolution.
  • Guaranteed leak-proof unit-dose packaging.

Dietary Supplement Technologies

  • ODF nutraceuticals, drinkable liposomal suspensions, where bad-taste or ingredient stability would defeat regular formulations.
  • Label-friendly excipients, sugar-free systems, and stability-first flavor systems.

How We Work: From Problem Statement to Launch at US Speed

  1. Problem Framing (Week 0–1)
    • Technical intake, Target Project Summary, claims guardrails, and Design for Manufacturability constraints (fill sizes, pack lines).
  2. Rapid Prototyping (Weeks 1–6)
    • Prototype formulation sprints; build A/B/C variants internally around critical vectors (pH, rheology, compatibility, stability, taste, performance panelist testing).
  3. Analytical & Stress Testing (Weeks 4–8)
    • Assay (titration / HPLC as needed), peroxide retention, rheometry (yield stress & thixotropy), accelerated stability (e.g., 50 °C), transport abuse (freeze-thaw), pH drifting, and packaging compatibility analysis (permeation, reaction, overall stability, etc.).
  4. Scale-Up + IQ/OQ (Weeks 8–10)
    • Pilot batches on coater/gel mixers, line trials on actual pouches/syringes/strips; set CQAs and in-process controls (fill mass, seal strength).
  5. Launch (Weeks 10–16)
    • Final specs, CoA templates, stability plan, artwork/label review; build safety & substantiation packets for your channel (professional/direct-to-consumer/e-commerce).

Case Studies (anonymized –  documentation available under NDA)

A) Heat-Stable Professional Whitening Gel: Summer Shipping, No Cold Chain

Challenge: A professional in-office whitening brand needed a high-potency peroxide gel that survives 50 °C freight temperatures without potency drop or phase separation.

Approach:

  • Engineered a water-based gel using peroxide-compatible polymers, oxygen-occlusal thickeners, and a tailored radical-scavenger matrix to slow autocatalytic breakdown.
  • Matched dual-syringe viscosities (±10%) to keep dose ratio stable across 20–45 °C.
  • Formulated the gel to be near-neutral pH for maximum user comfort and prevent sensitivity / pain during and after teeth whitening applications.Outcome:
  • <15% peroxide loss after 30 days @ 50 °C; zero bleed or leak in packaging; rapid chairside handling (no drip, smooth spread, easy application).
  • Commercialized in the US with repeat orders; post-launch complaint rate <0.3%.

B) High-Load Sublingual Film with Bitter Actives

Challenge: Deliver >35% actives in a fast-dissolving ODF with bitter notes.
Approach:

  • Built a sublingual film with taste-mask micro-encapsulation /PEG plasticizer blend, and moisture-blocking pouch.

    Outcome:
  • Disintegration ≤40 s (USP <2040>), CV of content ≤5%, and pouch residual moisture ≤3% at 6-month accelerated.
  • Scaled to continuous roll-to-roll with >95% yield after die-cut.

C) Two-Step Strip for On-Contact / In-Situ Activation During Application

Challenge: Two incompatible components needed to mix only at use.

Approach:

  • Designed a dissolvable activator strip with controlled-catalyzation time and a separate teeth whitening strip to direct react with the dissolvable strip on tooth contact.Outcome:
  • No premature flavor degradation in 12-week shelf testing; strong consumer usability scores.
  • Received a US patent (US9655818B1) for the ingenuity and innovation within 7 months.

Note: Several of our products are sold in prestige retail: Sephora, Ulta, Amazon, CVS, professional dental networks (DSO), and e-commerce; brand/retailer names and performance data are available under NDA with permission.

Quality, Compliance & Manufacturing at US Scale

  • Facility: US-based; cosmetic GMP aligned (ISO 22716); device-adjacent documentation where applicable.
  • QA/QC: Incoming raw verification, release testing, packaging stability, retain program, CAPA.
  • Packaging: Oxygen and moisture-barrier materials; dual-barrels, airless, pouches, sachets, suppositories, and unit-dose dispensers.
  • Supply chain: US and vetted global sources; alternate-vendor strategies to protect launches.

What to Bring to Your Scoping Call

  • Target Product Summary: claims, channel (professional/DTC/retail), pricing requirements.
  • Functional requirements: actives, flavor, peroxide level (if any), film size/thickness.
  • Performance targets: viscosity, pH, dose accuracy, taste.
  • Packaging preference: syringe/dual-chamber/strip/ODF pouch/suppository.
  • Timelines: prototype date, pilot, first PO.

Let’s Build What Others Won’t Attempt

Based in the USA. Fast to sample. Built for scale.

  • R&D kickoff: typically 2 weeks from TPP alignment.
  • Pilot & scale-up: plan for 6–8 weeks after prototype lock.
  • Engage us: info@atriumsci.com  |  Tel: (626) 380-5887. NDA available on request; we can start with a technical feasibility sprint or a full development program.
By botao Atrium R&D • Blog • Science • • • • • • 0 Comments

Our Nano-Complex Technology

What is a nano-complex?

In pharmaceutical terms, a nano-complex refers to a complex or combination of substances that are structured at the nanoscale level. It involves the formulation of active pharmaceutical ingredients (APIs) or therapeutic agents in a nano-sized delivery system.

Nano-complexes are designed to have specific properties and advantages compared to conventional drug delivery systems. By manipulating the size, shape, and composition of the particles or structures, nano-complexes can enhance the bioavailability, stability, and targeted delivery of drugs. They can also improve solubility, prolong drug release, and potentially overcome various barriers in drug delivery, such as crossing biological membranes or reaching specific tissues or cells.

The use of nano-complexes in pharmaceuticals allows for more precise control over drug delivery, optimizing therapeutic outcomes and minimizing potential side effects. Nano-complexes can be designed using different materials, such as lipids, polymers, or inorganic nanoparticles, depending on the specific requirements of the drug and the desired delivery mechanism.

Our groundbreaking nano-complex technology consists of incredibly small particles that do wonders for your teeth. These particles are created by combining active compounds such as hydrogen peroxide or phthalimidoperoxycaproic acid with a unique mix of natural polymers. These polymers have adhesive properties and are highly charged to help the particles stick to your teeth.

But that’s not all!  Our product goes beyond just sticking to your teeth. It forms a strong bond between your tooth enamel and the active compounds in our particles. This bond allows for a sustained release, which ensures that the beneficial ingredients work on your teeth over time.

To enhance your oral health even further, our composition may also include desensitizing agents, antibacterial agents, flavoring agents, enzymes, and more. These additional components work together to support your overall dental well-being.

Experience the power of our innovative formula and unlock the potential of a healthier, more radiant smile!

What are the benefits of nano-complexes for oral health?

Nano-complexes offer several potential benefits when it comes to delivering active ingredients for oral care purposes. Here are some of the advantages associated with the use of nano-complexes in oral care:

  1. Enhanced bioavailability: Nano-complexes can improve the bioavailability of active ingredients by increasing their solubility and stability. This means that a higher concentration of the active ingredient can be delivered to the desired site in the oral cavity, improving its effectiveness.

  2. Targeted delivery: Nano-complexes can be designed to target specific areas in the oral cavity, such as the teeth or gums. By encapsulating the active ingredients within nanoscale structures, they can be directed to the intended site, allowing for precise delivery and localized treatment.

  3. Extended release: Nano-complexes can provide sustained or controlled release of active ingredients over an extended period. This is beneficial for oral care products as it allows for a longer duration of action, ensuring that the active ingredients stay in contact with the teeth or gums for a prolonged period, promoting their effectiveness.

  4. Protection of active ingredients: Nano-complexes can protect active ingredients from degradation or inactivation in the oral cavity. The encapsulation within nanoscale structures shields the active ingredients from harsh oral environments, such as saliva or enzymes, ensuring their stability and preserving their efficacy until they reach the target site.

    Atrium Nano Complex Technology Platform

  5. Improved user compliance: Nano-complexes can enhance the sensory attributes of oral care products, such as taste and texture, making them more pleasant for patients to use. This can improve user compliance and encourage regular use of oral care products, leading to better oral health outcomes.