D.N.A. Defiant New Age™ Under Eye Anti-Aging Overnight Facial Patch

D.N.A. microneedle was originally developed as a way to deliver active ingredients painlessly into the skin. Dissolvable polymer microneedles are made by mixing active ingredients with dissolvable polymers to create a micron-sized needle shape that naturally dissolves away after skin insertion.

These offer various advantages:
• The microneedle is a painless way of delivering active ingredients compared with the syringe.
This can potentially improve the quality of life for those who would otherwise need frequent injections.
• The dissolvable microneedle is an environmentally friendly solution, leaving no dangerous or wasteful products behind, such as needles or glass, because microneedles dissolve into the skin after insertion.
• Cold-chain supply costs are reduced, because the solid state of the dissolvable microneedle enables greater stability during the distribution of various biopharmaceuticals without the need for refrigeration.


Atrium manufactures skincare microneedle patch products using hyaluronic acid as a matrix material.  These skincare products contain various active ingredients with proven effectiveness.  In addition, these products are very safe for the skin because they do not contain any preservatives.  There were no significant side-effects after using D.N.A. skincare products; this was tested by 25 clinical studies performed according to the good clinical practice guidelines. Also, there were no significant side-effects reported from consumers after using D.N.A. products.


Facial wrinkles are representative of skin ageing caused by reduction of skin elasticity and degradation of the extracellular matrix (ECM). Tao Radical has commercialized various wrinkle treatment microneedle patch products with a plethora of cosmetic companies. The matrix material of this microneedle is hyaluronic acid, which has been used as moisturizing and filling agent for many cosmetic products. This hyaluronic acid-based microneedle has wrinkle treatment efficacy by itself. Additionally, this product could be combined with a cream or essence type product for better wrinkle treatment efficacy. 

Epidermal growth factor (EGF) loaded microneedles showed significant wrinkle treatment efficacy after applying every day for 10 days (Figure 2a). This product also showed significant wrinkle treatment efficacy after applying twice a week for four weeks (Figure 2c).

Figure 2c shows a clinical result which indicates wrinkle improvement efficacy after two hours of application; the peak of observed eye wrinkle was significantly decreased after 2 hours of using the product.  These results indicate that this new product has fast-onset efficacy for wrinkle treatment.
Figure 2: Clinical trial results for wrinkle care efficacy of EGF loaded microneedle patch, with (A) once daily application for 10 days and (B) twice weekly application for 4 weeks. (C) Clinical efficacy of new wrinkle care product after 2 hours of application.


Sodium Hyaluronate Crosspolymer, Peptide-Complex, Pentylene Glycol, s-MU-Conotoxin.




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