D.N.A. Defiant New Age™ Under Eye Anti-Aging Overnight Facial Patch

D.N.A. microneedle was originally developed as a way to deliver active ingredients painlessly into the skin. Dissolvable polymer microneedles are made by mixing active ingredients with dissolvable polymers to create a micron-sized needle shape that naturally dissolves away after skin insertion.

These offer various advantages:
• The microneedle is a painless way of delivering active ingredients compared with the syringe.
This can potentially improve the quality of life for those who would otherwise need frequent injections.
• The dissolvable microneedle is an environmentally friendly solution, leaving no dangerous or wasteful products behind, such as needles or glass, because microneedles dissolve into the skin after insertion.
• Cold-chain supply costs are reduced, because the solid state of the dissolvable microneedle enables greater stability during the distribution of various biopharmaceuticals without the need for refrigeration.

SKINCARE APPLICATIONS

Atrium manufactures skincare microneedle patch products using hyaluronic acid as a matrix material.  These skincare products contain various active ingredients with proven effectiveness.  In addition, these products are very safe for the skin because they do not contain any preservatives.  There were no significant side-effects after using D.N.A. skincare products; this was tested by 25 clinical studies performed according to the good clinical practice guidelines. Also, there were no significant side-effects reported from consumers after using D.N.A. products.

WRINKLE TREATMENT

Facial wrinkles are representative of skin ageing caused by reduction of skin elasticity and degradation of the extracellular matrix (ECM). Tao Radical has commercialized various wrinkle treatment microneedle patch products with a plethora of cosmetic companies. The matrix material of this microneedle is hyaluronic acid, which has been used as moisturizing and filling agent for many cosmetic products. This hyaluronic acid-based microneedle has wrinkle treatment efficacy by itself. Additionally, this product could be combined with a cream or essence type product for better wrinkle treatment efficacy. 

Epidermal growth factor (EGF) loaded microneedles showed significant wrinkle treatment efficacy after applying every day for 10 days (Figure 2a). This product also showed significant wrinkle treatment efficacy after applying twice a week for four weeks (Figure 2c).

Figure 2c shows a clinical result which indicates wrinkle improvement efficacy after two hours of application; the peak of observed eye wrinkle was significantly decreased after 2 hours of using the product.  These results indicate that this new product has fast-onset efficacy for wrinkle treatment.
Figure 2: Clinical trial results for wrinkle care efficacy of EGF loaded microneedle patch, with (A) once daily application for 10 days and (B) twice weekly application for 4 weeks. (C) Clinical efficacy of new wrinkle care product after 2 hours of application.

Ingredients

Sodium Hyaluronate Crosspolymer, Peptide-Complex, Pentylene Glycol, s-MU-Conotoxin.

 

 

Research

1. McAllister DV et al, “Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: novel fabrication methods and transport studies”. Proc Natl Acad Sci, 2003, Vol 100(24), pp 13755-13760.
2. Ito Y et al, “Self-dissolving microneedles for the percutaneous absorption of EPO in mice”. J Drug Target, 2006, Vol 14(5), pp 255-261.
3. Lee JW, Park JH, Prausnitz MR, “Dissolving microneedles for transdermal drug delivery”. Biomaterials, 2008, Vol 29(13), pp 2113-2124.
4. Prausnitz MR, Langer R, “Transdermal drug delivery”. Nat Biotechnol, 2008, Vol 26(11), pp 1261-1268.
5. Bal SM et al, “Microneedle-Based Transcutaneous Immunisation in Mice with N-Trimethyl Chitosan Adjuvanted Diphtheria Toxoid Formulations”. Pharm Res, 2010, Vol 27(9), pp 1837-1847.
6. Park JH, Allen MG, Prausnitz MR, “Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery”. J Control Rel, 2005, Vol 104(1), pp 51-66.
7. Park JH, Allen MG, Prausnitz MR, “Polymer microneedles for controlled-release drug delivery”. Pharm Res, 2006, Vol 23(5), pp 1008-1019.
8. Gill HS et al, “Effect of microneedle design on pain in human subjects”. Clin J Pain, 2008, Vol 24(7), pp 585-594.
9. Sullivan SP, Murthy N, Prausnitz MR, “Minimally invasive protein delivery with rapidly dissolving polymer microneedles”. Adv Mater, 2008, Vol 20(5), pp 933-938.
10. Sullivan SP et al, “Dissolving polymer microneedle patches for influenza vaccination”. Nat Med, 2010, Vol 16(8), pp 915-920.
11. Lee JW et al, “Dissolving microneedle patch for transdermal delivery of human growth hormone”. Small, 2011, Vol 7(4), pp 531-539.
12. Lee K et al, “Drawing lithography: three-dimensional fabrication of an ultra-high-aspect-ratio microneedle”. Adv Mater, 2010, Vol 22(4), pp 483-486.
13. Kim JD et al, “Droplet-born air blowing: Novel dissolving microneedle fabrication”. J Control Rel, 2013, Vol 170(3), pp 430-436.
14. Yang H et al, “Centrifugal Lithography: Self-Shaping of Polymer Microstructures Encapsulating Biopharmaceutics by Centrifuging Polymer Drops”. Adv Healthcare Mater, 2017, Vol 6(19).
15. Ito Y et al, “Feasibility of microneedles for percutaneous absorption of insulin”. Eur J Pharm Sci, 2006, Vol 29(1), pp 82-88.
16. Indermun S et al, “Current advances in the fabrication of microneedles for transdermal delivery”. J Control Rel, 2014, Vol 185, pp 130-138.
17. Schoellhammer CM, Blankschtein D, Langer R, “Skin permeabilization for transdermal drug delivery recent advances and future prospects”. Exp Opin Drug Deliv., 2014, Vol 11(3), pp 393-407.
18. Nguyen TT, Park JH, “Human studies with microneedles for evaluation of their efficacy and safety”. Exp Opin Drug Deliv, 2017, Vol 30, pp 1-11.
19. Hong JY et al, “Efficacy and safety of a novel, soluble microneedle patch for the improvement of facial wrinkle”. J Cosmet Dermatol, 2017, Oct 7.
20. Kim S et al, “Enhanced Transdermal Delivery by Combined Application of Dissolving Microneedle Patch on Serum-Treated Skin”. Mol Pharm 2017, Vol 14(6), pp 2024-2031.
21. Park J et al, “Efficacy of Biodegradable Microneedle Patches on Periorbital Wrinkles”. Korean J Dermatol, 2014, Vol 52(9), pp 597-607.
22. Goldman MJ, Anderson GM, Stolzenberg ED, “Human betadefensin- 1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis”. Cell, 1997, Vol 88, pp 553-560.
23. Sieprawska-Lupa M et al, “Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases”. Antimicrob Agents Chemother, 2004, Vol 48(12), pp 4673-4679. 
24. Cabanes J, Chazarra S, Garcia- Carmona F, “Kojic acid, a cosmetic skin whitening agent, is a slowbinding inhibitor of catecholase activity of tyrosinase”. J Pharm Pharmacol, 1994, Vol 46(12), pp 982-985.
25. Chang TS, “An updated review of tyrosinase inhibitors”. Int J Mol Sci, 2009, Vol 10(6), pp 2440-2475.
26. Lee MR, Shumack S, “Prurigo nodularis: a review”. Australas J Dermatol, 2005, Vol 46(4), pp 211-218; pp 219-220.
27. Parisi R et al, “Global epidemiology of psoriasis: a systematic review of incidence and prevalence”. J Invest Dermatol, 2013, Vol 133(2), pp 377-385.
28. Lee JH et al, “A hyaluronic acid-based microneedle patch to treat psoriatic plaques: A pilot open trial”. Br J Dermatol, 2018, Vol 178, pp 24-25.
29. Zimmerman S et al, “A microneedlebased glucose monitor: fabricated on a wafer-level using in-device enzyme immobilization”. TRANSDUCERS 2003 – The 12th International Conference on Solid-State Sensors, Actuators and Microsystems, 2003, Vol 1, pp 99-102.
30. Mukerjee E et al, “Microneedle array for transdermal biological fluid extraction and in situ analysis”. Sens Actuators, A, 2004, Vol 114, pp 267-275.
31. Wang PM, Cornwell M, Prausnitz MR, “Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles”. Diabetes Technol Ther, 2005, Vol 7(1), pp 131-141.
32. Li CG et al, “One-touch-activated blood multidiagnostic system using a minimally invasive hollow microneedle integrated with a paperbased sensor”. Lab Chip, 2015, Vol 15(16), pp 3286-3292.
33. Donnelly RF et al, “Hydrogelforming microneedles increase in volume during swelling in skin, but skin barrier function recovery is unaffected”. J Pharm Sci, 2014, Vol 103, pp 1478-1486.
34. Romanyuk AV et al, “Collection of analytes from microneedle patches”. Anal Chem, 2014, Vol 86(21), pp 10520-10523.
35. Steele LS, Glazier RH, “Is donepezil effective for treating Alzheimer’s disease?”. Can Fam Physician, Vol 45, pp 917-919.
36. Affoo RH et al, “Swallowing dysfunction and autonomic nervous system dysfunction in Alzheimer’s disease: a scoping review of the evidence”. J Am Geriatr Soc, 2013, Vol 61(12), pp 2203-2213.
37. Kim JH et al, “Successful transdermal allergen delivery and allergen-specific immunotherapy using biodegradable microneedle patches”. Biomat, 2018, Vol 150, pp 38-48.

D.N.A. Defiant New Age™ Personal Lubricant

It can happen to anyone, you need a little extra moisture to keep things smooth. Be prepared and stay in the moment with our signature delivery enhanced Nano CBD lubricant. Our non-scented formula is close to the body’s own natural moisture, so you’ll feel confident and uninterrupted.

Benefits

  • Enhances intimate moments
  • Silky formula feels close to the body’s own natural moisture
  • Enhanced with calming Nano CBD to aid quick delivery

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply with hands or directly to the areas in need of extra lubrication before or during intimate moments, may be reapplied as needed.

Ingredients

Hyaluronic Acid, Chondrus Crispus Extract, Sodium Hyaluronate, Propanediol, Glycerin, Water, Hexapeptide-66, Cannabidiol.

D.N.A. Defiant New Age™ Stem Cell Moisturizer

The ultimate weapon of luxury to help fight cellular damage and promote a more youthful look and feel to skin. With a blend of peptides and growth factors in our liposomal delivery, your skin will appear less lined, firmer and younger looking. Improvement can be seen with continued use. Nano Encapsulated CBD for superior delivery.

Benefits

  • Contains Human Neonatal Fibroblast Conditioned Media
  • Contains Human Adipose Stromal Cell Conditioned Media
  • Improves the look and feel of skin and wrinkles
  • Anti-inflammaging Nano CBD to calm and soothe

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply small amount to clean dry skin one area at a time, gently massage in upward motion until fully absorbed.

Ingredients

PEG-8, Dimethicone, Cyclopentasiloxane, Dimethicone/Vinyl Dimethicone Crosspolymer, Nylon 6/12, Tetrahexyldecyl Ascorbate, Caprylic/Capric Triglyceride, Aloe Barbadensis Leaf Extract, Ascorbyl Methylsilanol Pectinate, Phytic Acid, Hydroxyacetic Acid/Glycolic Acid, Sodium Chloride
Panthenol (Pro-Vitamin B5), Camellia Sinensis Leaf Extract, Human Neonatal Fibroblast Conditioned Media, Human Adipose Stromal Cell
Conditioned Media, Phenoxyethanol, Ethylhexylglycerin, Cannabidiol.

D.N.A. Defiant New Age™ Pain Relief Cream

This potent blend of plant based ingredients is your go to for help with pain relief. Hemp derived anti-inflammatory Nano CBD delivery helps to calm aches and pains along with hemp seed extracts to help soothe and heal skin. MossCellTec helps skin adapt to environmental changes.

Benefits

  • Feels cooling and soothing on aches and pains
  • Anti-inflammatory and healing
  • Light peppermint scent smells pleasant
  • Contains anti-inflammaging Nano CBD to aid quick delivery

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply to muscle aches and pain to help with relief, swelling and bruising. May be reapplied every few hours as needed. May also be used as part of a stress relieving massage.

Ingredients

Phenoxyethanol, Ethylhexylglycerin, Glycerin (Vegetable derived), Xanthan Gum, Lecithin, Sclerotium Gum, Pullulan, Carthamus Tinctorius (Safflower) Oleosomes, Camellia Sinensis Seed Oil, Butyrospermum Parkii Oil (EU),
Butyrospermum Parkii (Shea) Butter (US), Hydrogenated Ethylhexyl Olivate, Hydrogenated Olive Oil Unsaponifiables, Cannabis Sativa (Hemp) Seed Oil, Dimethicone, Capsicum Frutescens Oleoresin, Oryza Sativa (Rice) Extract, Water, Cannabis Sativa Seed Extract, Physcomitrella Patens Protonema Extract, Isomalt, Butylene Glycol, Dextran, Palmitoyl Tripeptide-8, Pentapeptide-59, Hydrogenated Lecithin, Butyrospermum Parkii (Shea) Butter, Phenethyl Alcohol, Maltodextrin, Camellia Sinensis Leaf Extract, Algae Extract, Arnica Montana Flower Extract, Propanediol, Sodium Acrylates Copolymer, Lecithin, Mentha Piperita (Peppermint) Oil, Menthol.

D.N.A. Defiant New Age™ Massage Oil

Melt away stress with our freshly scented Nano CBD infused massage oil. Help relieve aches and pains with the benefits of calming, quick delivery Nano CBD, essential oils and massaging touch. Transport your senses and relaxation into blissful moments.

Benefits

  • Infused with Nano CBD to fight inflamm’aging
  • Contains calming Lavender Oil to aid in relaxation
  • Silky feel and slip for gentle or deep massage
  • Helps to calm aches, pains and relax muscles

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply enough oil to area of treatment, so that massage is smooth and hands glide over area without friction. Reapply as needed.

Ingredients

Helianthus Annuus (Sunflower) Seed Oil, Carthamus Tinctorius (Safflower) Seed Oil, Brassica Campestris (Rapeseed) Seed Oil, Prunus amygdalus dulcis (Sweet Almond) Oil, Limnanthes Alba (Meadowfoam) Seed Oil, Tocopheryl Acetate, Tocopherol, Cannabidiol, Lavandula Angustifolia Oil, Citrus Sinensis (Orange) Peel Oil.

D.N.A. Defiant New Age™ Body Lotion

Our Luxurious, fast absorbing formula will leave your skin supremely hydrated and silky. Contains Stemsvelt™ to help smooth cellulite and maintain smoother skin with continued use. Overtime skin will appear visibly firmer and less dimpled.

Benefits

  • Infused with anti-aging Nano CBD and skin smoothing Stemsvelt™
  • Leaves skin feeling hydrated and moist
  • Helps reduce the appearance of cellulite and dimpled skin
  • Fights Inflamm’aging

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply to desired areas of treatment and massage until absorbed into skin. Use anytime after bathing or desire extra hydration. Continue to use daily for maximum results.

Ingredients

Phenoxyethanol (and) Ethylhexylglycerin, Glycerin (Vegetable derived)
Xanthan Gum, Propanediol, Sodium Acrylate/Sodium Acryloyl Dimethyl
Taurate Copolymer, Cetyl Alcohol, Glycol Stearate, Glyceryl Stearate, Caprylic/Capric Triglyceride, Dimethicone, Cyclopentasiloxane, Olea Europaea (olive) oil, Vitis Vinifera (Grape) Seed Oil, Brassica Campestris (Rapeseed) Seed Oil, Polysorbate 20, Hydrolyzed Pumpkin Seed Cake, Cannabidiol, Water, Butylene Glycol, Silybin Marianum Extract, Vibrio Alginolyticus Ferment Filtrate, Mangifera Indica (Mango) Seed Butter, Orbignya Oleifera Seed Oil, Squalane, Phospholipids, Tocopheryl Acetate, Hydrolyzed Rice Protein, Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract.

D.N.A. Defiant New Age™ Eye Cream

Say goodbye to puffiness and dark circles and hello to a more hydrated, smoother appearing brighter eye area. Our peptide enriched and calming Nano CBD formula will help to contour and firm the eye area for a more defined and youthful appearance..

Benefits

  • Dark Circles and puffiness appear diminished
  • Delicate skin feels hydrated, smoother, firmer
  • Peptide and Nano CBD enriched formula calms, delivers and soothes
  • See results with continued use

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply a small amount to the surrounding eye area, and gently tap and lightly massage until absorbed. Wait a few minutes to see full results as this powerhouse formula goes to work.

Ingredients

Glycerin (Vegetable derived), Propanediol, Xanthan Gum, Polyglyceryl-6 Distearate, Jojoba Esters, Polyglyceryl-3 Beeswax, Cetyl Alcohol, Cetearyl Alcohol, Camellia Sinensis Seed Oil*, Butyrospermum Parkii Oil (EU), Butyrospermum Parkii (Shea) Butter (US), Hydrogenated Ethylhexyl Olivate, Hydrogenated Olive Oil Unsaponifiables, Cannabis Sativa (Hemp) Seed Oil, 
Dimethicone, Biphenyl Azepanyl Methanone, Water, Medicago sativa (Alfalfa) Seed Extract, Hydrolyzed Lupine Protein, Palmitoyl Tripeptide-5, Panthenol, Sodium Hyaluronate, Algae (Dunaliella Salina) Extract, Cannabidiol, Phenoxyethanol, Ethylhexylglycerin.

D.N.A. Defiant New Age™ Cell Nouveau Firming Serum

This Lightweight Serum, is a powerhouse of collagen nourishing vitamins, anti-aging ALGAKTIV® GenoFix, known to help DNA repair, ALGAKTIV® BioSKN to help cells regenerate, and ALGAKTIV® RestoreSKN to aid in rejuvenation and repair. Nano CBD completes the anti-aging, anti-inflammaging effects in this powerfully hydrating freshly scented formula.

Benefits

  • Promotes DNA repair for less wrinkled appearance
  • Liposomal delivery of active key ingredients for optimal results
  • Enhances collagen and cellular production
  • Vitamin packed formula with Nano CBD activates calming and healing

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: After cleansing, apply to neck and chest and massage in an upward motion. Follow with our StemCell Moisturizer for extra added moisture, and always use an SPF during the daytime.

Ingredients

Sucrose, Plankton Extract, Lecithin, Phenoxyethanol, Ethylhexylglycerin, Glycerin (Vegetable derived), Propanediol, Allantoin, Panthenol, Sodium PCA, Chondrus Crispus Extract, Sodium Hyaluronate, Water, Chlorella Vulgaris extract, Polyacrylate-13, Polyisobutene, Polysorbate 20, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Retinyl Palmitate, Helianthus Annuus
(Sunflower) Seed Oil, Caprylic/Capric Triglyceride, Dimethicone, Cannabidiol, Citrus Aurantium Bergamia (Bergamot) Peel Oil.

D.N.A. Defiant New Age™ Shampoo & Conditioner

Lather your strands in this exclusive CBD (100 mg) enriched D.N.A. shampoo. Gently cleans and helps to strengthen hair while soothing and nourishing your scalp. Invigorating, sulfate-free formula awakens your senses.

Benefits

  • Infused with anti-aging and calming Nano CBD
  • Helps protect color treated hair
  • Gentle formula safe for frequent use
  • Sulfate free formula

After cleansing with D.N.A. Shampoo, rescue your strands with our smoothing, hydrating and color protecting conditioner. Anti-aging Nano CBD-infused formula (100 mg) will help calm stressed hair and nourish scalp, imparting a beautiful shine and manageable look and feel to hair.

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply palm sized amount according to hair length and thickness, gently lather into hair, massaging scalp and strands. Rinse thoroughly and repeat if necessary.

Shampoo Ingredients

Phenoxyethanol, Ethylhexylglycerin, Sodium Hyaluronate, Polyquaternium-10, Acrylates Crosspolymer-4, Triethanolamine, Glycerin (Vegetable derived), Hydrolyzed Jojoba Esters, Sodium C14-16 Olefin Sulfonate, Cocamidopropyl Hydroxysultaine, Cocamide MIPA, Cocamidopropyl Hydroxysultaine, Sodium Cocoyl Glycinate, Polyquaternium 7, Panthenol, Triethylsiloxyamodimethicone, C11-15 Pareth-7, C12-16 Pareth-9, Trideceth-12, Silicone Quaternium-8, Trideceth-10, Cannabidiol.

Conditioner Ingredients

Water (Aqua), Aloe Barbadensis Leaf Extract, Ascorbyl Methylsilanol Pectinate, Phytic Acid, Triethanolamine, Propanediol, Panthenol, Glycerin (Vegetable derived), Hydrolyzed Jojoba Esters, Water (Aqua), Cetearyl Alcohol, Behentrimonium Chloride, Polyquaternium 37, Olea Europaea (olive) oil, Triethylsiloxyamodimethicone, C11-15 Pareth-7, C12-16 Pareth-9, Trideceth-12, Silicone Quaternium-8, Trideceth-10, Sodium Hyaluronate, Polyquaternium-10, Cannabidiol, Ethylhexylglycerin.

D.N.A. Defiant New Age™ Stem Cell Facial Serum

D.N.A. Hemp Extract Stem Cell Serum is a lightweight, potent, active complex of stem cells from Argan, Apple and Pumpkin plus 200 mg Hemp Extract.  Plant stem cells have been scientifically proven to help with anti-aging (https://www.ncbi.nlm.nih.gov/pubmed/25362798). In a base of pure soothing Aloe vera and an extract of an ancient herb called Gotu Kola, known to revitalize the appearance of the skin. Cassia extract provides natural hyaluronic acid while Rose essential oils boost the skins youthful, radiant looking complexion.

Benefits

  • For all skin types needing a boost
  • Can be used alone or under other moisturizers and makeup
  • Boost the skins youthful, radiant looking complexion
  • A must have in your skin care regimen

CBD has profound research and significant skin benefits; packed full of antioxidants and superior ability to moisturize, smooth and slow the appearance of aging in your skin.

CBD hemp extract also has significant skin softening properties. Cannabidiol gives the skin a smooth and moisturized appearance. It is a source of unsaturated fatty acids, phospholipids and phytosterols (a range of natural antioxidants), biominerals, Vitamins, carotenoids and chlorophylls. Research CBD for yourself, it is truly a remarkable ingredient. **

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply a few pumps in light circular massaging motions after cleansing and toning. Can be used alone or in conjunction with your favorite Tilvee creme.

Ingredients

Aloe vera (Aloe) leaf *, Oryza sativa (Rice bran) oil*, Caprylic/Capric Triglyceride (Coconut MCT), Vegetable glycerin*, Cannabis sativa (Hemp) extract,  Cucurbita pepo (Pumpkin seed extract & cell culture extract), Malus domestica (Apple fruit stem cell extract), Argania spinosa (Argan sprout stem cell extract), Centella asiatica (Gotu Kola extract), Helianthus annuus (Sunflower) seed oil, Cassia angustifolia (botanical hyaluronic acid), Olibanum (Frankincense) oil, Rosa damascena (Rose) oil.