D.N.A. Defiant New Age™ Under Eye Anti-Aging Overnight Facial Patch

D.N.A. microneedle was originally developed as a way to deliver active ingredients painlessly into the skin. Dissolvable polymer microneedles are made by mixing active ingredients with dissolvable polymers to create a micron-sized needle shape that naturally dissolves away after skin insertion.

These offer various advantages:
• The microneedle is a painless way of delivering active ingredients compared with the syringe.
This can potentially improve the quality of life for those who would otherwise need frequent injections.
• The dissolvable microneedle is an environmentally friendly solution, leaving no dangerous or wasteful products behind, such as needles or glass, because microneedles dissolve into the skin after insertion.
• Cold-chain supply costs are reduced, because the solid state of the dissolvable microneedle enables greater stability during the distribution of various biopharmaceuticals without the need for refrigeration.


Atrium manufactures skincare microneedle patch products using hyaluronic acid as a matrix material.  These skincare products contain various active ingredients with proven effectiveness.  In addition, these products are very safe for the skin because they do not contain any preservatives.  There were no significant side-effects after using D.N.A. skincare products; this was tested by 25 clinical studies performed according to the good clinical practice guidelines. Also, there were no significant side-effects reported from consumers after using D.N.A. products.


Facial wrinkles are representative of skin ageing caused by reduction of skin elasticity and degradation of the extracellular matrix (ECM). Tao Radical has commercialized various wrinkle treatment microneedle patch products with a plethora of cosmetic companies. The matrix material of this microneedle is hyaluronic acid, which has been used as moisturizing and filling agent for many cosmetic products. This hyaluronic acid-based microneedle has wrinkle treatment efficacy by itself. Additionally, this product could be combined with a cream or essence type product for better wrinkle treatment efficacy. 

Epidermal growth factor (EGF) loaded microneedles showed significant wrinkle treatment efficacy after applying every day for 10 days (Figure 2a). This product also showed significant wrinkle treatment efficacy after applying twice a week for four weeks (Figure 2c).

Figure 2c shows a clinical result which indicates wrinkle improvement efficacy after two hours of application; the peak of observed eye wrinkle was significantly decreased after 2 hours of using the product.  These results indicate that this new product has fast-onset efficacy for wrinkle treatment.
Figure 2: Clinical trial results for wrinkle care efficacy of EGF loaded microneedle patch, with (A) once daily application for 10 days and (B) twice weekly application for 4 weeks. (C) Clinical efficacy of new wrinkle care product after 2 hours of application.


Sodium Hyaluronate Crosspolymer, Peptide-Complex, Pentylene Glycol, s-MU-Conotoxin.




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D.N.A. Defiant New Age™ Stem Cell Moisturizer

The ultimate weapon of luxury to help fight cellular damage and promote a more youthful look and feel to skin. With a blend of peptides and growth factors in our liposomal delivery, your skin will appear less lined, firmer and younger looking. Improvement can be seen with continued use.


  • Contains Human Neonatal Fibroblast Conditioned Media
  • Contains Human Adipose Stromal Cell Conditioned Media
  • Improves the look and feel of skin and wrinkles

**These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Directions: Apply small amount to clean dry skin one area at a time, gently massage in upward motion until fully absorbed.


PEG-8, Dimethicone, Cyclopentasiloxane, Dimethicone/Vinyl Dimethicone Crosspolymer, Nylon 6/12, Tetrahexyldecyl Ascorbate, Caprylic/Capric Triglyceride, Aloe Barbadensis Leaf Extract, Ascorbyl Methylsilanol Pectinate, Phytic Acid, Hydroxyacetic Acid/Glycolic Acid, Sodium Chloride
Panthenol (Pro-Vitamin B5), Camellia Sinensis Leaf Extract, Human Neonatal Fibroblast Conditioned Media, Human Adipose Stromal Cell
Conditioned Media, Phenoxyethanol, Ethylhexylglycerin.

D.N.A. Defiant New Age™ Stem Cell Facial Serum

D.N.A. Stem Cell Serum is a lightweight, potent, active complex of stem cells from Argan, Apple and Pumpkin.  Plant stem cells have been scientifically proven to help with anti-aging (https://www.ncbi.nlm.nih.gov/pubmed/25362798). In a base of pure soothing Aloe vera and an extract of an ancient herb called Gotu Kola, known to revitalize the appearance of the skin. Cassia extract provides natural hyaluronic acid while Rose essential oils boost the skins youthful, radiant looking complexion.


  • For all skin types needing a boost
  • Can be used alone or under other moisturizers and makeup
  • Boost the skins youthful, radiant looking complexion
  • A must have in your skin care regimen

Directions: Apply a few pumps in light circular massaging motions after cleansing and toning. Can be used alone or in conjunction with your favorite Tilvee creme.


Aloe vera (Aloe) leaf *, Oryza sativa (Rice bran) oil*, Caprylic/Capric Triglyceride (Coconut MCT), Vegetable glycerin*,  Cucurbita pepo (Pumpkin seed extract & cell culture extract), Malus domestica (Apple fruit stem cell extract), Argania spinosa (Argan sprout stem cell extract), Centella asiatica (Gotu Kola extract), Helianthus annuus (Sunflower) seed oil, Cassia angustifolia (botanical hyaluronic acid), Olibanum (Frankincense) oil, Rosa damascena (Rose) oil.

D.N.A. Defiant New Age™ Starfish Cellular Anti-Aging Cream

D.N.A. Cellular Anti-Aging Cream increases firmness of the skin while delivering powerful anti-wrinkle action by starfish extract (no starfish is harmed in the process of extraction). Clinically proven to reduce the number of depth of both deep and medium-deep wrinkles after a 28 day application. Includes Vitamin E, C, A, and Aloe Vera as anti-oxidants and sooth the skin.

The D.N.A. StarFish Cellular Anti-Aging Cream is a superb solution to regain a younger, glowing, and radiant appearance.  It provides exceptional barrier and protection, and leaves the skin supple and bright, while promoting the natural cell regeneration process. It also prevents water from leaving the skin, and increases long-term cell health. This long-lasting cellular regeneration essence provides unprecedented radiance.

Starfish Extract’s Safe Retinol-Mimetic Action, is the New and Unique Way to Attenuate Visible Signs of Skin Aging without Any Adverse Effects

Skin aging is a continuous and permanent process. Aging induces degradation of many skin properties and functions, with a gradual loss of barrier function, a slower turnover of epithelial cells as well as a decrease in the quality and functionality of the extracellular matrix.

But who said skin aging is inevitable?

Keeping a glowing and healthy-looking skin is part of a positive outlook on aging. Through years of clinical research and innovation, we unlocked the amazing regenerating secret of starfish using a harmless process to deliver a superior natural anti-wrinkle ingredient.

Retinol-Etinol-Mimetic Action

Retinoids, such as retinol, are the gold standard of topical anti-aging products. Topical application of retinol is effective in reducing the signs of intrinsic aging and repairing photo damaged skin. Cell regeneration, exfoliation, and dermal collagen synthesis are all stimulated by retinol applications. However, the positive clinical results obtained with retinol are offset by several side effects (Kockaert & Neumann 2003), including erythema, peeling, dryness, and pruritus. Factors determining the efficacy and safety of retinol are concentration, stability, encapsulation method and formulation. Despite of efforts to counter the negative effects of retinol, users often stop their retinol treatment before it produces noticeable results.

With D.N.A. Starfish Extract, Atrium Unlocked One of the Most Powerful Secrets of Nature, the Regenerative Potential of The Mighty Starfish

Starfish are among the most common and intriguing marine organisms. Despite their simple structure, starfish possess unique regenerative properties allowing them to regrow entire limbs following predators’ attacks.

After years of R&D, our scientific team successfully developed a harmless harvesting process, allowing collection of starfish coelomic fluid without affecting its viability.

Our unique ECOcoelomic Fluid Collecting Process is a circular economy process performed in collaboration with mussel growers. This beautiful island is bathed by the cold waters of the Atlantic, hosting vast starfish populations. Starfish play a complex role in the marine environment, mainly by regulating the population of mollusks and crustaceans. But they are also an effective predator of mussels that need to be controlled around mussel growing sites.

In collaboration with mussel growers, we developed a sustainable collection of starfish that helps control starfish population around their installations while not harming the starfish population. Each starfish that is captured is maintained alive and returned to its natural habitat after coelomic fluid collection. This practice allows starfish to completely recover and resume their normal life.

Routine quality control and quality assurance protocols are used in the selection of starfish, coelomic fluid collection and handling process to ensure that starfish population remains stable around harvesting sites.

Ecocoelomic Fluid Collection Process

  1. Harvesting of starfish in partnership with mussel fishermen;
  2. Transportation to mobile collecting facilities in sea water tanks;
  3. Non-harmful and soft coelomic fluid collecting, micro-filtering;
  4. Formulation of D.N.A. Starfish Extract;
  5. Reintroduction the starfish back to their natural marine environment.


  • Reduced wrinkles and fine lines
  • Reduced under eye puffiness
  • Hydrate skin
  • Repair and regenerate damaged skin tissues

Proven Efficacy

A cream containing 1.6% of D.N.A. Starfish Extract was applied twice daily (27 volunteers, aged 40 to 70), during 28 days. This clinical study has shown significant results on wrinkle depth, wrinkle volume, elasticity, firmness and moisturization.

The video below shows the first 24h of the recolonization process by normal human keratinocytes in culture, comparing the control cells (top) to cells treated with starfish coelomic fluid from D.N.A.’s Asteria vulgaris (bottom).

Starfish coelomic fluid treatment doubled the speed of keratinocyte recolonization of the injured area.

In a clinical study using a 1.6% D.N.A. Anti-Aging cream or a placebo, mean values of wrinkles depth, width and volume were calculated for each subject, before and after 28 days of application of the test product.

After only 28 days of application, D.N.A. induced a significant reduction in wrinkles depth and volume of 18% and 21% respectively. This reduction was also significant when compared to the placebo with respectively 12% and 15%.

Starfish Extract In-Vitro Efficacy

Normal keratinocytes from a 49 year-old donor were placed in a culture medium until confluence. An artificial wound was created by performing a scratch in the cellular monolayer, leaving a clear space that keratinocytes can recolonize. Keratinocytes cultures were treated with growth media (Control), TGF-β (a known wound healing promoting factor) and coelomic fluid from Asteria vulgaris starfish (final concentration 0.048%). Promotion of wound healing is seen as increased recolonization of the wounded area.

Pictures of the wounded area were taken at baseline (A), and after 24h of recolonization under the control (B), TGF-β (C) or coelomic fluid (D) treatments, showing a clear, positive regenerative impact of coelomic fluid on wound healing process.

Recolonization under control conditions reached 60.5% after 24h, while use of TGF-β stimulated keratinocyte recolonization to reach 88.7%. The use of coelomic fluid promoted significantly stronger recolonization than control as well as TGF-β, with 96.4% of recolonization after 24h.

Ex-Vivo Efficacy

Analysis of skin layers’ morphology was conducted after 6 days of topical application of 1.6% D.N.A. Starfish Extract (or retinol cream) on skin explants from a 60-year-old female donor.

The effects show D.N.A. Starfish Extract helps stimulate thickening of the epidermis more than a comparable retinol cream, while provoking none of the side effects of retinol.

Collagen & Gag Synthesis

Analysis of type III and IV collagen and glycosaminoglycan synthesis after 6 days of topical application of 1.6% D.N.A. Starfish Extract (or retinol cream) was performed on skin explants from a 60-year-old female donor.


Water, Aloe Vera concentrate, glycerin, tetrasodium
ethylenediaminetetraacetic acid tetrasodium salt, caprylic / capric triglyceride, isoeicosane, glyceryl stearate, Vitamin C Palmitate, cetyl alcohol, Vitamin E Acetate, starfish coelomic fluid, Algae Extract.

D.N.A. Defiant New Age™ UV Nail Top / Base Gel Coat

Experience the Revolution: Our 100% Non-Toxic UV Nail Gels, Based on DentalGrade 3D Printing Technology

Bring your manicure to life with Defiant New Age Nail Polish. This specially formulated UV-Activated Top/Base coat is the ultimate in UV curable coating. D.N.A. leaves a durable, long wearing, high gloss shine over polish. Dries layers of polish in just 3 minutes under any UV lamp.


  • 100% Non-toxic dental-grade organic formulation
  • Shiny and almost mirror-like finish
  • Provides protection from breakage by preventing nail polish from chipping or wearing off
  • Protects nail colors up to 4 weeks
  • 100% Made in USA – Redefine Quality and Safety


Ethyl Acetate, Butyl Acetate, Cellulose Acetate Butyrate, Isopropyl Alcohol, Acetyl Tributyl Citrate, Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer, Acrylates Copolymer, Benzophenone-3, Trimethylpentanediyl Dibenzoate, CI 60725 (Violet 2).

JoS™ Intensive Joint Pain Relief

An all-natural product that delivers powerful benefits of plant extracts, antioxidants and essential oils

Our JOS™ cream is an all-natural product that delivers powerful benefits of plant extracts, antioxidants and our proprietary blend of essential oils such as Camphor, Peppermint, and Tea Tree Leaf to provide reliable relief to sore muscle & joints.  This natural topical cream provides maximum bioavailability for the active ingredients to penetrate deep into the skin’s dermal layers for maximum effect.

Each batch of our product is hand made precisely to ensure the highest quality. Your muscles and joints will feel relief within 2 days as the ingredients are absorbed into the skin and built-up around affected areas.  The cream also leaves a soothing scent and has a skin moisturizing effect without being greasy.


  • Reported to significantly reduce tension related to sore muscles and improve quality of life within 2 days
  • Each batch is hand made precisely to ensure the highest quality
  • Micro-encapsulated plant extracts for fast absorption and high bioavailability
  • All plant-based ingredients including a proprietary blend of powerful anti-inflammatory and soothing essential oils delivered by pharmaceutical grade skin penetration enhancers
  • Made in the USA


Water (Aqua), Arnica Montana Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Glycerin, Glyceryl Stearate, PEG-100 Stearate, Cetyl Esters, Steareth-20, Pyridoxine Hydrochloride (Vitamin B6), Methylsulfonylmethane (MSM/DMSO2), Glucosamine (Vegetable Source), Bilineurine Bitartrate, Ethoxydiglycol, Cetyl Myristoleate, Aloe Barbadensis (Aloe Vera) Leaf Extract, Butyrospermum Parkii (Shea Butter), Boswellia Serrata (Frankincense) Oil, Mentha Piperita (Peppermint) Oil, Cinnamomum Camphora (Camphor), Melaleuca Alternifolia (Tea Tree) Leaf Oil, Vitamin E, Dipotassium Glycyrrhizinate, Ammonium Acryloyl-Dimethyltaurate/VP Copolymer, Phenoxyethanol, Iodopropynyl Butylcarbamate.