A Platform for Advanced Oral Transmucosal Delivery
HarmonyFilm™ delivers improved solubility, bioavailability, and ease of use for a better consumer experience.
HarmonyFilm™ is our orally dissolvable film technology platform for optimizing the bioavailability and metabolism of therapeutic active ingredients. Orally dissolvable film technology is a versatile dose form for creating custom products with optimal release profiles, supported by our ongoing research and formulation development efforts.
HarmonyFilm™ products are about the size of a stamp, and can deliver therapeutic actives through the oral mucosal tissue sublingually or buccally. Oral transmucosal drug delivery is a non-invasive route that allows for the active ingredients to be absorbed directly into the vascularized tissue in the mouth, bypassing the hepatic first pass effect. This leads to reduced drug exposure and can offer a rapid onset of action.
Active ingredients in the HarmonyFilm™ can be either water-soluble or encapsulated for more effective absorption and sustained release. As oral dissolvable films dissolve quickly, no water is required for their consumption, improving user compliance – especially among children, and in conditions where users have difficulty in swallowing.
Suitable Actives for Sublingual Thin Films
Oral thin films work best when the active ingredient is low-dose. The active ingredients in films are often incorporated as solid dispersions / nanosuspensions / micronized powders and are typically ~5–30% by weight of the film matrix.
Best-fit categories:
High-Potency Micronutrients (micro to low-mg)
Examples: vitamin B12, folate, biotin, vitamin D3 / K2, iodine/selenium (trace minerals).
Typical workable dose: ~0.05–10 mg.
Fast-Onset Functional Ingredients
Fast-onset “functional” actives that are effective at low doses
Examples: melatonin, caffeine, certain nootropic alkaloids/extract actives.
Typical workable dose: ~1–70 mg.
Standardized Plants Extracts
Examples: high-potency standardized extracts.
Typical workable dose: ~10 – 70 mg (higher loads often make films gritty / bitter).
Lipophilic Actives
Examples: certain terpenes, fat-soluble vitamins, CoQ10-type actives with solubilization (emulsified/complexed) to avoid crystallization.
Typical workable dose: ~1–70 mg.
Peptides / Fragile Actives
Feasible when low dosage and protected/encapsulated.
Typical workable dose: mcg to low mg.
Poor-fit Categories (not viable in films)
High-dose minerals (Ca, K) and “gram-dose” amino acids.
Bulky botanicals that need 300–1000 mg per dose.
HarmonyFilm Sublingual ODF Film Benefits
- No unpleasant aftertaste, unlike pills
- Direct absorption into the bloodstream
- No need for water or swallowing
- Precise dosing + faster onset
- Discreet
- Available in any flavor
- Multiple actives up to 150mg
- Potential for reduced side effects with a lower dose
Our custom system delivers:
- Multi-Formulation Run
- Precision-Engineered Drying
- Guaranteed Dosage Accuracy
- Film Integrity & Fast Dissolving
- Fully Automated
- High Production Output
- Computer-Aided Automatic Film Alignment
Ready to launch your sublingual film product? Contact us to start your project today.